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Berkeley Springs is located on US-522, between Lewistown, Pennsylvania and Hancock, Maryland in the north, and Winchester, Virginia in the south. It's just south of the junction of I-68 — which leads west toward Cumberland, Maryland and Morgantown — and I-70 — which runs from Somerset, Pennsylvania in the west to Hagerstown, Maryland in the east. To the east of Berkeley Springs is I-81, which passes from Hagerstown to Winchester through Martinsburg.